Congenital abnormalities of brain development

Congenital defects, anomalies, defects in brain development

Numerous developmental defects in children arise due to disruption of intrauterine embryogenesis.
Congenital anomalies in the fetus and newborn child are detected immediately by the appearance of the skull or several years after the onset of neurological disorders. Depending on the location, migration disorders of cerebral tissue cause certain clinical symptoms. The acute course of the pathology will allow neurologists to make a diagnosis in a timely manner. Chronic development with cycles of exacerbations and remissions is not a specific sign of nosology.

Diagnosis of brain development abnormalities:

Modern diagnostics are designed to detect severe cerebrovascular malformations in the perinatal period, during ultrasound screening of pregnancy.
Anomalies of brain development are often incompatible with life and lead to intrauterine death or death in the first months after birth. If alarming neurological and neuropsychiatric symptoms arise during the child’s life, it is necessary to contact a pediatric neurologist. To accurately diagnose the cause of your symptoms, your doctor may prescribe:

• MRI of the brain. This is the most informative method of visualizing brain structures, with which the vast majority of anatomical abnormalities are detected;
• Neurosonography. Ultrasound of the brain for children under 1 year of age, through the fontanel;
• Electroencephalography (EEG). Registration of electrical signals from the brain.
• Long-term video-EEG monitoring.

Brain dysplasia - what is it?

Limited cerebral damage in a limited area provokes a variety of clinical manifestations. Epileptic seizures are combined with impaired consciousness and cortical disorders.

Initial signs of nosology using electroencephalography. Minor cerebral changes can be treated with anticonvulsants.

Types of focal dysplasia:

• The first type is a local change in cortical architectonics;
• The second type is focal cytoarchitectonic changes;
• The third type is pathology of architectonics in secondary diseases (temporal sclerosis, cerebral malformation, Rasmussen's encephalitis, ischemia).

Methods of radiation neuroimaging MRI of the brain in St. Petersburg help verify the stage of nosology.

Polycystic dysplasia of the brain is characterized by the presence of many cystic growths within the cerebral tissue.

To diagnose defects, the results of CT and MRI are compared

Treatment of brain development abnormalities:

Treatment is predominantly symptomatic. For epilepsy, therapy with antiepileptic drugs is selected. In case of mental development and speech disorders, neurocorrection and classes with speech pathologists are carried out.

If the identified brain malformation is operable and the prognosis for surgical treatment is favorable, the patient can be referred to a neurosurgeon to decide on surgical treatment in specialized institutions.

At the St. Luke Health and Development Center, qualified pediatric neurologists, child psychiatrists, and epileptologists receive treatment. Our specialists have extensive experience in diagnosing and treating neurological pathologies.

Anomalies of brain stem development - causes

Depending on the morphological changes, groups of brain abnormalities are distinguished:

1. Regulations;
2. Quantities;
3. Size and shape;
4. Structures (buildings).

The first group of nosologies arises due to underdevelopment of the rudiment of the cerebral structure or the complete absence of the embryonic rudiment. If the baby is born normal, the prognosis is poor due to the absence of part of the brain.

Positional anomalies include the doubling of an organ, the merging of several parts together at the same time.

Defects in the position of cerebral structures

All nosological forms of the group are determined by three factors:

1. Inversion displacement of the organ relative to its own axis, median position;
2. Dystopia is an unusual localization of embryonic structures;
3. Heterotopia is a pathology of organ anlage.

The degree of displacement is determined by the severity of clinical symptoms and a person’s life expectancy.

Defects in brain size and shape

The list of nosologies in this category is determined by a number of morphological changes:

• Synostosis of several organs;
• Hyperplasia - an increase in the number of tissues and sizes of cerebral tissues;
• Dysplastic hypoplasia – reduction in the size of the structure;
• Simple hypoplasia - no changes in morphology.

Defects in brain structure

The nosology is accompanied by anomalies in the natural formation of the hole and morphological features of the structure. Heteroplasia develops at the stage of intrauterine development. Characterized by atypical tissue formation.

Dysplasia is a pathology of the relationship of articular surfaces.

Hamartria is the abnormal development of tissue structures. Stenotic narrowing of the canal or duct can be congenital or acquired.

A dysontogenetic cyst is accompanied by a significant narrowing of the compensatory capabilities of the organ.

Classification of embryonic developmental defects:

• Fetopathies;
• Embryopathies;
• Blastopathy;
• Gametopathies.

Depending on the time of occurrence of defects in embryonic development, a certain type of disorder occurs.

Based on the extent of damage, the following types of cerebral defects are distinguished:

• Multiple – affects several brain areas at once;
• Systemic – localized within one area;
• Isolated - cause damage to one organ.

Congenital anomalies of the central nervous system can be provoked by infectious agents:

• Toxoplasma;
• Cytomegalovirus;
• Coxsackie virus.

Alcohol abnormalities occur if a pregnant woman drank alcohol during pregnancy. The pathology is provoked by chromosomal aberrations and genetic mutations during the formation of the neural tube (third or fourth week of pregnancy).

Causes of brain development abnormalities:

• Infections suffered by the mother during pregnancy. The most dangerous in this regard are toxoplasmosis, rubella, cytomegalovirus, and encephalitis;
• Exposure to chemical, radiological factors;
• Bad habits of the mother: nicotine addiction, drug use, psychotropic substances, alcohol consumption;
• Use of certain pharmacological drugs. The child’s nervous system is formed literally from the first days after conception - at this time the expectant mother may not even be aware of pregnancy and use medications that have a harmful effect on the fetus;
• Diseases associated with metabolic disorders, in particular decompensated diabetes mellitus;
• Direct genetic dependence (on average, 1-2% of all cases).

Main types of brain defects

Defects in shape, size, and location of individual anatomical structures are identified. Let's consider the main types of congenital anomalies of brain development.

What is encephalocele

Penetration of cerebral tissue through skull defects causes various neurological symptoms, depending on the characteristics of the site of prolapse. Mild anencephaly resembles a cephalohematoma, but skull radiography reveals midline cleft and asymmetrical areas.

With the help of surgical intervention, it is possible to eliminate the pathology, but large lesions cannot be eliminated by ectopic protrusion. Encephalocele is verified by radiation neuroimaging methods - MRI and CT.

Features of anencephaly

The pathology is characterized by the absence of individual bones of the skull. The sites of destruction are overgrown with connective tissue, which does not allow optimal regulation of intracranial pressure.

Most nosological forms are incompatible with life. Death occurs immediately after birth, when the lungs open and the supply of oxygen to the cerebral parenchyma begins.

Manifestations of microcephaly

Underdevelopment of cerebral tissue occurs in one child out of five thousand newborns. The nosology is determined by a decrease in the size of the cranium, a violation of the relationship between the brain and the facial part of the skull.

Microcephaly (Giacomini syndrome) develops in utero in women with infections and parasitic diseases.

Causes of primary microcephaly:

• Genetic abnormalities with autosomal recessive transmission;
• Toxoplasmosis, cytomegalovirus encephalitis, rubella.

Etiological factors of secondary microcephaly:

• Cerebral cysts;
• Calcifications and hemorrhages inside the brain parenchyma.

A decrease in the size of the skull is characterized by about ten percent of oligophrenia. From an early age, the child exhibits developmental delays and closed developmental defects. Mental retardation is accompanied by convulsive syndrome. Muscle twitching is accompanied by improper development of the brain part of the skull.

What is macrocephaly characterized by?

Enlargement of the cranium allows diagnosing pathology. The nosology is characterized by hypertrophy of one hemisphere, disproportionate development of one half. Mental retardation is the most common manifestation. Seizures occur in approximately nine to ten percent of patients.

The clinic of nosology appears during the first years of life, which allows timely verification of pathology. Brain migration disorders are too severe for effective treatment of the disease.

Symptoms of holoprosencephaly

Holoprosencephaly is a disease accompanied by a defect in the development of the hemispheres. The lack of separation between the cerebral halves causes changes in the activity of functional centers.

Severe dysplasia leads to ventricular anomalies, asymmetry of the facial and brain parts. Severe defects lead to necrosis of the cerebral parenchyma with a high probability of death in the first days after the birth of the child.

The formation of a single hemisphere is a congenital defect due to a genetic abnormality of the thirteenth to fifteenth chromosomes. Nosology is often combined with other developmental defects:

1. Cyclopia;
2. Ethmocephaly;
3. Cebocephaly.

The disease is accompanied by stillbirth. The ability to survive is minimal. The prognosis is unfavorable.

Clinic of cerebral cystic dysplasia

Multiple cystic cavities cause migration disorders. Developmental defects are accompanied by abnormalities in the distribution of cerebrospinal fluid. Numerous cysts cannot be removed. Often provoke muscle cramps. Low effectiveness of anticonvulsant treatment leads to progression of symptoms.

Single cysts may not pose a danger. Subclinical symptoms may occur due to increased intracranial hypertension.

How does agyria manifest itself?

Lissencephaly is a defect in the formation of the architectonics of the cerebral cortex. Severe convulsions are caused by underdevelopment of the cerebral convolutions. Nosology shapes motor and mental manifestations. Neurological signs of the disease – Lennox-Gastaut syndrome, Vesta.

The coherence of the brain provokes paralysis, paresis, and polymorphic convulsions. Signs of nosology develop in the first year of life. The baby lives for approximately this period of time.

Clinical signs of pachygyria

The developmental defect is due to the lack of formation of the secondary and tertiary gyri. Straightening the grooves of the second type disrupts the cerebral architecture.

The pathology of the layered structure of the cortex is characterized by heterotopia of nerve cells. MRI shows pachygyria well.

Clinical symptoms of craniostenosis

The disease is characterized by a narrowing of the skull with compression of the brain between the bones. Depending on the progression, decompensated and compensated variants of the nosology are distinguished.

According to the characteristics of the course, stable and progressive forms of the disease are distinguished. More often, the causes are due to early healing of the coronal or sagittal sutures. Pathology without timely treatment leads to death, as brain infringement occurs. Clinical symptoms depend on the predominant localization of the zone of compression of the white matter and parenchyma.

Neurological symptoms are characterized by numerous disorders against the background of increased intracranial pressure.

A child with craniostenosis has a severe headache, so the baby is restless, irritable, and whiny. Memory loss and impaired concentration occur when the condition persists for a long time. The prognosis of the pathology is unfavorable.

Indicators of agenesis of the corpus callosum

Nosology is characterized by underdevelopment of the corpus callosum. Concomitant pathology is underdevelopment of the third ventricle of the brain. Hypoplasia provokes underdevelopment of muscle muscles, paresis and paralysis, muscle cramps.

Manifestations of Aicardi syndrome occur when underdevelopment of the corpus callosum is combined with chorioretinal defects. The clinical picture is complemented by myoclonic convulsions, the formation of numerous lacunar nodes in the retina and optic nerve head. The nosology is characterized by microphthalmia, pendulum-like eye movements.

Some researchers have identified X chromosome defects in men in patients with agenesis of the corpus callosum.

Micropolygyria Clinic

The disease occurs due to the formation of numerous small convolutions. The normal cerebral cortex has six layers. With an anomaly, four layers can be traced. The abnormal structure leads to clinical symptoms:

1. Swallowing disorder;
2. Pathology of masticatory and facial muscles;
3. Oligophrenia;
4. Facial paraplegia.

The onset of the disease is observed in the first year of life.

Clinical manifestations of heterotopia

The nosology arises from neuronal migration. The lack of nerve signal transmission occurs due to heterotopions - pathological accumulations in the form of a ribbon or nodular form.

Due to heterotopia, mental retardation, epileptic syndrome, and various muscle cramps appear.

Diagnosis of congenital brain defects

Most nosological forms are detected initially by clinical manifestations. Mild course, hypotonic muscle contractions provoke convulsive syndrome in children of the first year of life.

Instrumental diagnostic methods - ultrasound, neurosonography, MRI and CT - can exclude hypoxic and traumatological manifestations. The procedures are sufficient to identify developmental anomalies, cysts, and heterotopic areas.

Electroencephalography detects areas of increased cerebral activity in the presence of convulsive muscle twitches. Congenital species require genetic diagnostics to study DNA and determine mutations of the chromosomal apparatus.