Modern life is characterized by high rhythm, as well as increased mental and physical stress. Lack of sleep, constant stress and other negative factors impair memory and reduce concentration. This leads to a deterioration in the quality of life in general. With age, the risks of developing negative deviations increase. The nootropic drug Semax will help stop age-related changes, increase performance and improve memory.
Release form and composition
The nootropic drug Semax belongs to the group of new generation drugs in the class of regulatory peptides. It is produced in the form of nasal drops. 1 ml of the drug contains 1 mg of methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline. This substance has psychostimulating, neuroprotective, antioxidant and antihypoxic effects.
Drops are offered in two forms: bottles with a pipette or complete with a dropper. The volume of the drug is always the same, but the percentage composition of the active substance is different and can be 0.1% and 1%.
Impact
Semax drops, the instructions confirm this, have a neurometabolic effect on the central nervous system when used in small doses. When used, it is possible to improve attentiveness and stimulate memory development. This allows you to quickly assimilate new information, which means increasing learning rates. In addition, it reduces the body’s negative reactions during oxygen starvation or cerebral ischemia.
The neuroprotective effect of the drug allows you to stop and limit areas of brain damage. As a result, it is possible to increase the effectiveness of restorative therapy for various pathological processes.
With increasing doses of Semax nasal drops, they additionally have antioxidant, angioprotective and antihypotoxic effects. This minimizes the development of problems due to oxygen starvation caused by decreased blood flow to the brain.
The active substance is absorbed from the nasal mucosa at rates of 60-70%. It spreads quickly throughout the body. Therefore, a positive result is obtained even after a single dose in the shortest possible time.
Due to the simple chemical structure of the drug, incompatible combinations with other drugs are excluded. The active substance does not enter the bloodstream through the gastrointestinal tract.
"Semax 1%" - ambulance for stroke
"Semax 1%" is a dosage of the drug specially designed for the treatment of stroke. The concentration of the active substance is 10 times greater than in Semax 0.1%.
To maintain the normal state of brain tissue and metabolic processes in neurons during a vascular accident - stroke - medications from the groups of neuroprotectors and neurometabolics are used.
The intranasal route of administration gives Semax enormous advantages over neuroprotectors and neurometabolics in the form of injections or tablets - after all, their effectiveness is significantly limited because, in addition to the blood-brain barrier, blood clots stand in their way, which prevent the medicine from penetrating the dying brain cells.
But “Semax 1%” - nasal drops - in a matter of minutes gets from the mucous membrane through the olfactory nerves directly into the damaged area of the brain to save cells from death.
Within a few minutes after Semax hits the nasal mucosa, it begins to act in the affected area of the brain. In the case of a stroke, this is especially important, because the life-saving molecule helps the patient not just survive, but recover and return to normal activities.
When are Semax drops prescribed?
Semax, the instructions for use indicate this, is used when symptoms appear that indicate impairment of memory and intelligence. They occur most often against the background of vascular lesions, traumatic brain injuries, and neurosurgical operations. The drug is indicated during the recovery period after a stroke, for neurotic disorders of various origins and dyscirculatory encephalopathy.
Semax is prescribed, the instructions for use confirm this, in extreme situations when it is necessary to increase the adaptive capabilities of the human body. The medicine is considered effective for the prevention of mental fatigue. It is able to maintain performance during monotonous work or performing operations in stressful situations.
The medicine is used in ophthalmology. He is appointed:
- In the complex treatment of optic nerve atrophy. This disease often leads to vision loss.
- With optic neuritis, which develops against the background of infection or inflammation and is characterized by degradation of visual function.
The product can be used in pediatrics. Drops are indicated for children over 7 years of age to eliminate minimal brain dysfunction. The drug is considered effective for attention deficit hyperactivity disorder.
Rules for taking Semax 0.1%
Reception 20 days
2 drops in each nasal passage 2 times a day, last instillation before 17:00
Course 3 bottles 2-3 courses per year Recommended: August, December, April
- the bottle contains 60 drops
- instillation should be carried out strictly on the nasal mucosa, avoiding leakage into the nasopharynx
Parents can console themselves with the fact that mobility and disobedience are common to all children. But if situations where teachers, educators, parents cannot come to an agreement with the child become a system, then there is a problem.
from attention deficit hyperactivity disorder. In boys, the problem occurs approximately 2-3 times more often than in girls. It is important to remember that ADHD is a behavioral disorder. Behavioral disorder.
Violation of social behavior is most often observed in children and adolescents, as well as a variant of pathology in persons suffering from neuropsychiatric diseases, which is most often reversible and normalizes with adequate treatment, as well as as the child grows older.
Signs of impaired concentration in children:
- The child constantly forgets or loses things;
- Forgetfulness that concerns important daily tasks, such as school homework;
- It seems that the child cannot or does not want to listen to the task or cope with it;
- Rapid loss of interest in any activity, frequent switching of attention;
- Problems with self-organization, inability to complete more tedious or time-consuming tasks.
Signs of hyperactivity and impulsivity:
- With ADHD, children cannot sit in one place for a long time, especially in a quiet, calm environment;
- Excessive talkativeness and mobility, even in a situation where the child is asked to sit still or quietly;
- Inability and unwillingness to wait for one’s turn;
- Action without premeditation;
- The urge to intervene in a conversation, to interrupt the interlocutor;
- Reduced or absent sense of danger.
Terms of use
The product is intended for intranasal administration. A pipette or dropper is used to ensure accurate dosage. The recommended amount is 2-3 drops in each nasal passage. If the doctor recommends an increased dosage, then the medicine should be administered with a break of at least 10 minutes.
Recommended dosages for various disorders and pathological conditions are given in the instructions for use. But they can be adjusted by the doctor during the treatment process depending on the patient’s condition and the results obtained.
Contraindications and negative reactions of the body
The main contraindications for Semax drops are hypersensitivity to the active component. The medicine is not prescribed to children under 7 years of age. Its use is contraindicated when carrying a child and during breastfeeding. This is due to the fact that studies have not been conducted to prove safety for the fetus and newborn child.
It is necessary to stop using the drug if you confirm:
- Acute psychotic disorders, which are characterized by difficulties assessing reality.
- Conditions of internal anxiety that cause dizziness, panic, muscle tension, shortness of breath.
- History of seizures, characterized by involuntary contraction of muscle groups.
There were no side effects when taking the medication. Sometimes minor irritation of the mucous membrane may occur. Signs of overdose were not affected even with repeated dosage increases.
You can find both positive and negative reviews about the drug. Many patients emphasize that after the course of treatment, memory and concentration have significantly improved. Many also note a positive effect associated with slowing the progression of dementia.
All negative reviews, as a rule, contain information that there is no positive result. Negative side reactions of the body are also often observed, due to which it was necessary to abandon the medicine.
Semax drops called 0.1% vial 3ml with sample pipette dosing
Registration Certificate Holder
PEPTOGENE Innovative Research and Production Center (Russia)
Dosage form
Medicine - Semax® (Semax)
Description
Nasal drops 0.1%
colorless, transparent.
1 l
methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline 1 g
Excipients
: methyl parahydroxybenzoate (nipagin) - 1 g, purified water - up to 1 l.
3 ml - bottles with a plastic screw cap with an attached pipette with a lid (1) - cardboard packs. 3 ml - bottles with a plastic dropper cap (1) - cardboard packs.
Indications
- intellectual-mnestic disorders in vascular lesions of the brain;
- recovery period after a stroke;
- encephalopathy;
- transient cerebrovascular accidents (TIA);
- conditions after traumatic brain injury, neurosurgical operations and anesthesia;
- neurotic disorders of various origins, incl. after ionizing radiation;
- to increase the body's adaptive capabilities in extreme situations;
- to prevent mental fatigue;
- during monotonous operator activity;
- work under stressful conditions.
In ophthalmology
- optic nerve atrophy;
- Optic neuritis of inflammatory or toxic-allergic etiology.
In pediatrics
- as a nootropic agent in children over the age of 7 years in the treatment of minimal brain dysfunction (including ADHD - attention deficit hyperactivity disorder).
Contraindications for use
- acute mental conditions (no studies conducted);
- anxiety disorders (not studied);
- history of seizures (no studies performed);
- children under 7 years of age (no studies have been conducted);
- children and adolescents under 18 years of age in ophthalmological and neurosurgical practice (no studies have been conducted);
- pregnancy (no studies have been conducted);
- lactation period (no studies conducted);
- hypersensitivity to the components of the drug.
pharmachologic effect
Semax® nasal drops 0.1% is an original synthetic peptide drug, which is an analogue of the ACTH4-10 fragment (methionyl-glutamyl-histidyl-phenylalanyl-prolyl-glycyl-proline), completely devoid of hormonal activity. All amino acids are L-form.
The drug has an original mechanism of neurospecific action on the central nervous system. It is a synthetic analogue of corticotropin, which has nootropic properties and is completely devoid of hormonal activity. The drug affects processes associated with memory formation and learning. Strengthens attention when learning and analyzing information, improves the consolidation of the memory trace in patients after neurosurgical interventions, traumatic brain injury, suffering from cerebrovascular diseases, incl. dyscirculatory encephalopathy; improves the body's adaptation to hypoxia, cerebral ischemia, anesthesia and other damaging influences.
The drug is practically non-toxic with single and long-term administration. Does not exhibit allergic, embryotoxic, teratogenic and mutagenic properties. Does not have a local irritant effect.
Drug interactions
Pharmaceutical
Based on the chemical structure of the drug, chemically incompatible combinations are not expected: the drug is quickly destroyed and does not enter the gastrointestinal tract.
Pharmacokinetic
Considering the chemical structure of the drug (heptapeptide is a synthetic analogue of ACTH, completely devoid of hormonal activity), the rate of absorption and rate of entry into the blood, as well as the intranasal route of administration, the influence of other drugs on the pharmacokinetic parameters of Semax® nasal drops 0.1% is not expected.
Considering the method of administration of the drug Semax® nasal drops 0.1%, it is undesirable to administer drugs that have a local vasoconstrictor effect when administered intranasally.
Dosage regimen
Semax® is used intranasally, using a bottle sealed with a plastic screw cap or a dropper cap.
1 drop of standard solution contains 50 mcg of active substance. The drug solution is administered using a pipette into each nasal passage in an amount of no more than 2-3 drops. If it is necessary to increase the dose, administration is carried out in several doses at intervals of 10-15 minutes.
For intellectual-mnestic disorders with vascular lesions of the brain, discirculatory encephalopathy, transient disorders of cerebral circulation
a single dose is 200-2000 mcg (at the rate of 3-30 mcg/kg). The daily dose is 800-8000 mcg (at the rate of 7-70 mcg/kg). The drug is prescribed 2-3 drops in each nasal passage 4 times a day for 10-14 days, if necessary, the course of treatment is repeated.
After traumatic brain injury, neurosurgical operations and anesthesia
a single dose is 1400-3500 mcg (40-50 mcg/kg) 3 times a day for 3-5 days. If necessary, the course of treatment is extended to 14 days.
To increase the body's adaptive capabilities and prevent mental fatigue
— for 3-5 days, 2-3 drops in each nasal passage 2-3 times in the morning. Daily dose 400-900 mcg. If necessary, the course of treatment is repeated.
For diseases of the optic nerve
the drug is instilled 2-3 drops into each nasal passage 2-3 times a day.
The daily dose is 600-900 mcg. The course of treatment is 7-10 days. In addition, the drug can be administered by endonasal electrophoresis:
the drug is administered from the anode; current strength - 1 mA; Duration of exposure - 8-12-15 minutes. The daily dose is 400-600 mcg. The course of treatment is 7-10 days.
Children aged 7 years and older
for
minimal cerebral dysfunction,
1-2 drops are prescribed in each nasal passage (at the rate of 5-6 mcg/kg) 2 times a day (morning and afternoon). The daily dose is 200-400 mcg. The course of treatment is 30 days.
Mode of application
If the bottle is sealed with a plastic screw cap:
- For initial use, you must remove the plastic screw cap and replace it with the supplied pipette with cap;
- draw the drug into a pipette;
- slightly tilting your head to the side, squeeze out the required number of drops of the drug onto the mucous membrane of the nasal passage.
If the bottle is sealed with a dropper cap:
- it is necessary to carefully cut off the tip of the pipette and tightly close the pipette with the cap;
- Before use, you should turn the bottle over so that the liquid fills the entire space of the pipette;
- remove the cap and, slightly tilting your head to the side, squeeze out the required number of drops of the drug onto the mucous membrane of the nasal passage.
The drug should be kept tightly closed with a capped pipette or plastic screw cap or dropper cap.
Overdose
Until now, it has not been possible to identify symptoms of a drug overdose even with a significant increase in a single dose.
Side effect
With prolonged use, slight irritation of the nasal mucosa is possible.
special instructions
Use in pediatrics
Use in children and adolescents under 18 years of age in ophthalmological and neurosurgical practice is contraindicated. No clinical studies have been conducted.
Storage conditions
The drug should be stored out of the reach of children, protected from light at a temperature not exceeding 10°C; do not freeze.
Best before date
Shelf life: 2 years.
An opened bottle should be stored at a temperature not exceeding 25°C for no more than 30 days.
Use during pregnancy and breastfeeding
Restrictions during pregnancy - Contraindicated. Restrictions when breastfeeding - Contraindicated. Use during pregnancy and lactation is contraindicated, because no clinical studies have been conducted.
Use in children
Restrictions for children - With caution. Contraindicated in children under 7 years of age; in ophthalmological and neurosurgical practice - for children and adolescents under the age of 18 years.
Terms of sale
The drug is available with a prescription.
Contacts for inquiries
PEPTOGENE Innovative Research and Production Center CJSC (Russia)
PEPTOGENE Innovative research and production center
123458 Moscow, Tvardovskogo st. 8, p. 1 Tel
