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Nootropil®

Inside.

During meals or on an empty stomach, with liquid.

If oral administration is not possible, the drug is administered intravenously in the same dose.

For intellectual-mnestic disorders:

2.4 - 4.8 g/day in 2-3 doses.

Treatment of cortical myoclonus:

Treatment begins with a dose of 7.2 g/day, every 3-4 days the dose is increased by 4.8 g/day to a maximum dose of 24 g/day in 2-3 doses.

The use of other drugs for the treatment of myoclonus should be continued at the same dosage. Depending on the effect obtained, the dose of these drugs should be reduced if possible.

Treatment with piracetam should be continued as long as symptoms of the disease persist.

In patients with acute episodes of myoclonus, spontaneous improvement may occur, so attempts should be made to reduce the dose or discontinue the drug every 6 months. To do this, gradually reduce the dose by 1.2 g/day every two days (in the case of Lance-Adams syndrome, every 3-4 days to prevent a possible sudden relapse or withdrawal syndrome).

Dosage in patients with impaired renal function:

Piracetam is excreted almost exclusively by the kidneys; caution should be used when treating patients with renal failure or requiring monitoring of renal function. The half-life increases in direct proportion to the deterioration of renal function and creatinine clearance; this is also true in the elderly, in whom creatinine excretion varies with age.

The dose should be adjusted depending on the creatinine clearance (CC):

Creatinine clearance for men can be calculated from the serum creatinine concentration (CSC) using the following formula:

CC (ml/min) = [140 - age (years)] x body weight (kg)/72 X Serum (mg/dl)

Creatinine clearance for women can be calculated by multiplying the resulting value by a factor of 0.85.

Kidney failure	CC (ml/min)	Dosage regimen
Norm	>80	usual dose in 2-4 doses
Lightweight	50-79	2/3 of the usual dose in 2-3 doses
Average	30-49	1/3 of the usual dose in 2 divided doses
Heavy	<30	1/6 of the usual dose once
Terminal stage	—	contraindicated

In elderly patients, the dose is adjusted in the presence of renal failure; with long-term therapy, monitoring of the functional state of the kidneys is necessary.

Dosage in patients with impaired liver function:

Patients with impaired liver function do not need dose adjustment. For patients with impaired renal and liver function, dosing is carried out according to the dosing schedule (see section “Dosing for patients with impaired renal function”).

Pharmacodynamics and pharmacokinetics

The active ingredient is piracetam. The use of the drug Nootropil enhances the utilization of glucose, enhances the synthesis of phospholipids and RNA, increases the level of ATP in brain tissue, and stimulates glycolytic reactions . The drug has a positive effect on metabolic processes in brain tissue, facilitates the learning process, improves integrative work and brain activity, and improves memory . Nootropil is able to suppress the aggregation of activated platelets, does not have a vasodilatory effect, but at the same time has a positive effect on microcirculation and the speed of propagation of the excitation wave in brain tissue. In case of brain damage due to intoxication, hypoxia, or electric shock, the drug has a pronounced protective effect, reducing the severity of vestibular nystagmus, reduces delta activity and enhances alpha and beta activity on the electroencephalogram . The medication improves cerebral blood flow, increases mental performance, improves conductivity between synapses in neocortical structures, and has a positive effect on interhemispheric connections. The therapeutic effect of treatment develops gradually. The drug does not have psychostimulating and sedative effects.

The drug is quickly absorbed, is not metabolized, and does not bind to blood proteins. It is excreted unchanged by the kidneys.

Nootropil price, where to buy

The price of Nootropil tablets is 275 rubles for 30 pieces of 800 mg each. You can buy Nootropil in the same release form in Ukraine for 80-100 hryvnia.

The price of Nootropil 20% solution ampoules of 5 ml is 315 rubles for 12 pieces. In Ukraine - 170 hryvnia.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

LuxPharma* special offer

Nootropil tab.
800 mg No. 30 RUB 1,390 order
Nootropil tab. 1200 mg No. 20
RUB 1,460 order

Pharmacy24

Nootropil 1200 mg No. 20 tablets USB Pharma S.A., Belgium
119 UAH order
Nootropil 200 mg/ml 5 ml No. 12 solution Eisika Pharmaceuticals S.R.L., Italy
168 UAH order
Nootropil 800 mg No. 30 tablets USB Pharma S.A., Belgium
95 UAH order

PaniPharmacy

Nootropil ampoule Nootropil solution 20% amp. 5ml No. 12 Italy, Aesica Pharmaceuticals
180 UAH order
Nootropil tablet. p/o 1200 mg No. 20 Ukraine, UCB Pharma
143 UAH order
Nootropil tablets Nootropil tablets. p/o 800 mg No. 30 Belgium, UCB Pharma
112 UAH order

Nootropil

Nootropil (active ingredient - piracetam) is a nootropic drug that is a derivative of gamma-aminobutyric acid. Nootropil can be called a reference nootropic without any exaggeration. The mechanism of its action is associated with influencing the course of metabolic and bioenergetic processes in neurons, accelerating the turnover of information molecules and stimulating protein synthesis. The effect of piracetam on oxygen utilization and glucose metabolism is determined by the conditions in which the drug acts - aerobic or anaerobic. In the first case, nootropil increases oxygen consumption and the breakdown of glucose by an average of 30%. In conditions of oxygen deficiency, the drug stimulates glycolysis due to the activation of the pentose phosphate pathway, which results in the formation of one of the main energy sources for metabolism in the brain - NADPH. In addition, under anaerobic conditions, nootropil increases ATP synthesis. At the cellular level, the drug interacts with polar groups of phospholipids, forming mobile complexes. This ensures the restoration of the two-layer structure of the cell membrane and maintains its stability. Nootropil facilitates various types of synaptic transmission, affecting mainly the activity and density of receptors on postsynaptic membranes (data were obtained during preclinical studies). Nootropil improves cognitive functions such as memory, attention, thinking, without having a psychostimulating (or, on the contrary, sedative) effect. Nootropil also affects the rheological properties of blood: in patients suffering from sickle cell anemia, the drug increases the ability of erythrocyte membranes to deform, thins the blood and prevents the formation of unstable erythrocyte aggregates - the so-called. “coin columns” characteristic of polyglobulia. In addition, nootropil reduces platelet aggregation (sticking together) without increasing/decreasing the number of the latter. In preclinical trials, it was found that the drug prevents vascular spasms and counteracts the substances that cause them.

In clinical studies, nootropil prevented the adhesion of red blood cells to the vascular endothelium and stimulated the secretion of prostacyclins.

After oral administration, nootropil is quickly and completely absorbed from the gastrointestinal tract. After taking 3.2 g of the drug, the maximum concentration of the active substance in the blood plasma is achieved after 1 hour. A hearty snack slows down this process by an average of 20%. The half-life of nootropil is 4-5 hours (from blood plasma) and 8.5 hours (from cerebrospinal fluid). The route of administration of the drug into the body does not affect the half-life. Nootropil is excreted from the body unchanged by the kidneys. Renal failure increases the half-life of the drug; liver failure does not affect this indicator.

Nootropil is available in four dosage forms: tablets, capsules, solution for intravenous and intramuscular administration, and solution for oral administration. The dose is calculated based on the patient's body weight. Oral forms of nootropil should be taken on an empty stomach or with food. Nootropil should be taken by patients with obvious hemostasis disorders, large-scale surgical interventions, severe bleeding, and renal failure under close and constant medical supervision. If a patient experiences sleep disturbances while taking nootropil, it is recommended to stop taking the drug in the evening and combine it with daytime use.

Nootropil is a “friendly” drug in relation to other drugs, however, it can also enter into some unwanted interactions. Thus, when it is combined with thyroid hormones, central effects may appear: somnological disturbances, irritability, anxiety, tremor, confusion. When nootropil is combined with central nervous system stimulants, potentiation of the effects of the latter may be observed. And finally, when taking antipsychotics together with nootropil, the risk of extrapyramidal disorders increases.

special instructions

Treatment with Nootropil requires regular monitoring of the functioning of the renal and hepatic systems, the state of peripheral blood , the level of creatinine and residual nitrogen. Drug therapy can be combined with psychoactive drugs and medications for the treatment of cardiovascular diseases. Treatment of acute lesions of tissues and structures of the brain is recommended to be carried out in combination with methods of restorative medicine and detoxification therapy . For psychiatric diseases, psychoactive drugs are simultaneously prescribed. Abrupt discontinuation of the medication is unacceptable, especially when treating patients suffering from cortical myoclonus ( due to the high risk of recurrence of seizures and seizures). If side effects such as insomnia or excessive drowsiness develop, it is recommended to stop taking the medication in the evening. During hemodialysis, Nootropil penetrates through special filter membranes in the device. Piracetam affects the ability to drive a vehicle.

The drug is not described in Wikipedia.